Hair Cell Regeneration

@teejayess said:

Is that the new Shingix compared to the older Zostavax? I posted a bunch of links on these above. I normally have no reaction to vaccines, but the first Shingrix left me bruised, sore and exhausted for four days,

I had the old Zostavax. Not yet had the Shingrix. I did read through the threads above and did not see a discussion of the relative effectiveness and presumed that most people were talking about the rep of Zostavax - for instance, donnie17048 just mentions “the shingles vaccine” - so I wanted to make a point that it is no longer “the shingles vaccine” and the new one is far more efficacious. Everyone should get that one, even if they’ve had the old one, and you’ve set a good example for us all by doing both!

@teejayess said:

I normally have no reaction to vaccines, but the first Shingrix left me bruised, sore and exhausted for four days, the second one three months later was not as bad, but still the soreness and lack of energy for two days

The Wikipedia article on Zoster vaccines is pretty good. It discusses the relative efficacy and the side effects of Zostavax (the old one ) and Shingrix (the new one). It does say that for the new one (Shingrix) some temporary side effects are likely but that’s a relatively mild price to pay for >90% efficacy, according to the Wikipedia article.

Zoster vaccine5

A zoster vaccine is a vaccine that reduces the incidence of herpes zoster (shingles), a disease caused by reactivation of the varicella zoster virus, which is also responsible for chickenpox. Shingles provokes a painful rash with blisters, and can be followed by chronic pain (postherpetic neuralgia), as well as other complications. Older people are more often affected, as are people with weakened immune systems (immunosuppression). Both shingles and postherpetic neuralgia can be prevented by v...

@jim_lewis said:

Everyone should get that one, even if they’ve had the old one, and you’ve set a good example for us all by doing both!

@jim_lewis said:

It does say that for the new one (Shingrix) some temporary side effects are likely but that’s a relatively mild price to pay for >90% efficacy,

Since we are so OT as it is, 13 years ago on this coming Halloween day, I had two stents placed in my heart. I always stayed active, ate well, took care of myself, or so I thought. When I saw the cardiologist five days after the cardiac cath, he stated I was very lucky, since the LAD is known as the “widowmaker” and one does not usually get warning (I did thanks to ongoing hard physical exertion and paying careful attention to “insignificant” body signs).

He told me I might have celebrated Thanksgiving, but not Christmas.

That pushed me to be more deeply involved in assuring I did everything possible to take the best care of myself possible. Knowing you were weeks away from your “final scene” is powerful motivation.

Shortly after I received Zostavax I started losing my hearing. It is now profound. Not saying that was the cause but very suspicious

I tried to look up via the CDC how to report a possible adverse vaccine reaction event. On the following page, down in the lowering right, is a link about reporting but it is unfortunately broken. However, the broken link initiates a web search by my ISP, instead of giving me an HTML 404 error, to other sites related to the text in the broken link. Maybe one of those other links would provide a way to report to the CDC your adverse event, either by yourself or even better with the help of your provider. That way if there were an overlooked connection between whichever of the two vaccines you took and your hearing loss, your contribution would help elucidate something that’s so far been over looked.
https://www.cdc.gov/vaccinesafety/index.html3

Thanks for the tip on the value of the accessories. It’s so great to get the reassurance of experienced forum members that the accessories are worth acquiring!

I am from Taiwan,My English language is not good. SORRY
I found this
http://www.kumc.edu/school-of-medicine/otolaryngology/about-the-department/faculty-and-staff/faculty/hinrich-staecker.html23
I do not know is it helpful?

Since the Shingrix vaccine has been discussed in this forum and a lot of us are old folks who perhaps should get this far more effective shingles vaccine (better than the original Zostavax), I thought the following Washington Post article on the incredible demand for the vaccine might be of interest:
https://www.washingtonpost.com/health/2018/12/07/all-i-want-christmas-is-shingles-vaccine-its-nearly-impossible-find/

UPDATE: Actually, the most important lines out of the article might be on how the vaccine scarcity is making it hard or impossible for users to get the 2nd required booster shot at the recommended interval. A bit contrary to the article, my wife (an M.D.) says of the numbers of patients that she has prescribed the shot to, none have yet been unable to get it in central Texas. Quote from article:

"Complicating the situation is the recommendation for consumers to get their second dose within two to six months of the first. Many consumers are struggling to find their second dose. Pharmacies are supposed to give priority to those patients. Some pharmacies are requiring consumers to get their second dose at the same place they got their first shot. Others will give the second shot if consumers show proof they have gotten the first one, regardless of where. GSK said preliminary data show that more than 70 percent of people have completed the series.

Consumers are understandably confused."

The Zostavax allegedly causes serious side effects, including painful rashes, hearing loss, and even blindness. If you have been given the Zostavax and suffered from any of these side effects, you may be entitled to compensation for your injuries, lost wages, medical bills, pain and suffering, and other losses. You need to find a lawyer that deals with medical cases.

Just wanted to share the latest news on ear hair cell regeneration! Here’s a synopsis of the study:

<<The zebrafish has emerged as a powerful model for studying sensory hair cell regeneration. Like other fish, zebrafish contain a network of sensory hair cells throughout their body to detect changes in water movement. The hair cells are located in small organs in the skin called neuromasts, which also contains cell types that are remarkably similar to those found in the mammalian inner ear. To study the genetic program of hair cell regeneration in zebrafish, we sequenced the RNA of individual cells within neuromasts, allowing us to classify cell types based on their gene expression signature. This included cells transitioning from support cells to fully mature sensory hair cells, thereby identifying new genes that are expressed during hair cell development. In addition, we characterized the role of the growth factor fgf3, and found that it acts to inhibit hair cell progenitor proliferation. Our results were published in the journal eLife1 on Jan. 25, 2019. Future work will examine the function of these genes in sensory hair cell regeneration.>>

Having been born BALD as an EGG in my inner ears (and no wonder I have sensorineural hearing loss!), I’m always daydreaming about the day when these hairs can be regenerated.

@1Bluejay said:

I’m always daydreaming about the day when these hairs can be regenerated.

Did you miss this? They have been regenerated.

Frequency Therapeutics announces breakthrough small-molecule approach to regenerate inner ear sensory hair cells

“In the Phase 1/2 study, FX-322 was safe and well tolerated following a single intratympanic injection with no serious adverse events. In addition, improvements in hearing function, including audiometry and word scores, were observed in multiple FX-322 treated patients.” Am I the only one who sees this as significant?

Back in August, 2018, this thread went a bit off topic on shingles vaccination as one poster thought that his/her hearing loss had something to do with shingles vaccination. Several people, including me, chimed in on their experience with shingles vaccination. A couple folks recounted that the newer, more effective vaccine, Shingrix, was very painful, etc.

Just wanted to update those reports with my own experience. I had my first shot of Shingrix about 24 hours ago. I previously had Zostavax about 8 years ago. I guess I’m one of the lucky ones. I experienced no unusual discomfort at the site of injection in my arm or in my overall disposition, alertness, any feeling of fatigue, etc. A little pain with the injection itself and maximum soreness, like a moderate bruise, about 4 hours after the injection. Today I feel great.

I got my shot at Walmart. Still had to get on a list to get the injection. The pharmacist who injected me told me that Shingrix is still in short supply but claimed that CDC has decided that the advised two to six month time window to get the 2nd REQUIRED follow-up shot for effectiveness is not supercritical. She said that if you can’t meet that window, it will be OK: the CDC says (she claimed) that the important thing is just to get the 2nd shot. She said that I can go anywhere to get the second shot and my insurance will still cover it. For the insurance that I have (Medicare, Blue Cross/Blue Shield), there is zero cost to me.

CDC advice to professionals on administering Shingrix: https://www.cdc.gov/vaccines/vpd/shingles/hcp/shingrix/recommendations.html2

On the following page, under “Dose Schedule” (down a bit), CDC discusses timing but I have been unable to find the advice the pharmacist gave me on the CDC website with a cursory search: Recommendations of the Advisory Committee on Immunization Practices for Use of Herpes Zoster Vaccines | MMWR1

Just wanted to post to note the lack of any real pain with my Shingrix injection and the pharmacist’s claim that the CDC now views the most important thing is just to get the 2nd shot (a definite waiting period is required after the first shot, though).

Jim, My experience with my first shot was like yours–essentially no symptoms. The second one I had a day with mild flu like symptoms, achy, mild fever and lethargic. Definitely glad I did it as I’ve known enough people who got Shingles to prefer to reduce my odds. My wife got her second shot at about 6 weeks and I see CDC implies that anything after 4 weeks is ok.

@MDB said:

My experience with my first shot was like yours–essentially no symptoms

Had you previously had the Zostavax shingles vaccine? Just curious if some pre-existing immunity helps clamp down on the body’s reaction to Shingrix.

Yes, I had the Zostavax previously. I think this kind of stuff is remarkably random.