Writing this in hopes of helping someone else with the same issue. First issue was fresh download of Patient Base. I am using Windows 11 and for some reason could not get a good download. Thanks to Tenkan kind suggestion, switched to Chrome and no problem.
Next problem was with opening ProFit from Patient Base. After using for several months, got a message stating Patientbase Server Not Available. After digging into it with a Microsoft tech, seems was a problem in handshaking between Patient Base and the local Windows server and how both were handling the patient database (I do not know what I am talking about, but repeating the tech’s words). Ended up having to re-install Windows. Was a pain, but now it works. Hope this helps someone.